TY - JOUR U1 - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed) A1 - Gehan, Olivier A1 - Pigeon, Eric A1 - Menard, Tomas A1 - Mosrati, Ridha A1 - Pouliquen, Mathieu A1 - Fall, Lamine M. A1 - Reuter, Johannes T1 - Dissolved oxygen level output feedback control based on discrete-time measurements during a Pseudomonas putida mt-2 fermentation JF - Journal of Process Control N2 - In this paper, the problem of controlling the dissolved oxygen level (DO) during an aerobic fermentation is considered. The proposed approach deals with three major difficulties in respect to the nonlinear dynamics of the DO, the poor accuracy of the empirical models for the oxygen consumption rate and the fact that only sampled measurements are available on-line. A nonlinear integral high-gain control law including a continuous-discrete time observer is designed to keep the DO in the neighborhood of a set point value without any knowledge on the dissolved oxygen consumption rate. The local stability of the control algorithm is proved using Lyapunov tools. The performance of the control scheme is first analyzed in simulation and then experimentally evaluated during a successfull fermentation of the bacteria over a period of three days. Pseudomonas putida mt-2 KW - Aerobic fermentation KW - DO control KW - Continuous-discrete time observer KW - Nonlinear output feedback Y1 - 2019 SN - 0959-1524 SS - 0959-1524 SN - 1873-2771 SS - 1873-2771 U6 - https://doi.org/10.1016/j.jprocont.2018.10.004 DO - https://doi.org/10.1016/j.jprocont.2018.10.004 VL - Vol. 79 IS - July SP - 29 EP - 40 ER -