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The influence of sleep on human life, including physiological, psychological, and mental aspects, is remarkable. Therefore, it is essential to apply appropriate therapy in the case of sleep disorders. For this, however, the irregularities must first be recognised, preferably conveniently for the person concerned. This dissertation, structured as a composition of research articles, presents the development of mathematically based algorithmic principles for a sleep analysis system. The particular focus is on the classification of sleep stages with a minimal set of physiological parameters. In addition, the aspects of using the sleep analysis system as part of the more complex healthcare systems are explored. Design of hardware for non-obtrusive measurement of relevant physiological parameters and the use of such systems to detect other sleep disorders, such as sleep apnoea, are also referred to. Multinomial logistic regression was selected as the basis for development resulting from the investigations carried out. By following a methodical procedure, the number of physiological parameters necessary for the classification of sleep stages was successively reduced to two: Respiratory and Movement signals. These signals might be measured in a contactless way. A prototype implementation of the developed algorithms was performed to validate the proposed method, and the evaluation of 19324 sleep epochs was carried out. The results, with the achieved accuracy of 73% in the classification of Wake/NREM/REM stages and Cohen's kappa of 0.44, outperform the state of the art and demonstrate the appropriateness of the selected approach. In the future, this method could enable convenient, cost-effective, and accurate sleep analysis, leading to the detection of sleep disorders at an early stage so that therapy can be initiated as soon as possible, thus improving the general population's health status and quality of life.
Identifikation von Schlaf- und Wachzuständen durch die Auswertung von Atem- und Bewegungssignalen
(2021)
Preliminary results of homomorphic deconvolution application to surface EMG signals during walking
(2021)
Homomorphic deconvolution is applied to sEMG signals recorded during walking. Gastrocnemius lateralis and tibialis anterior signals were acquired according to SENIAM recommendation. MUAP parameters like amplitude and scale were estimated, whilst the MUAP shape parameter was fixed. This features a useful time-frequency representation of sEMG signal. Estimation of scale MUAP parameter was verified extracting the mean frequency of filtered EMG signal, extracted from the scale parameter estimated with two different MUAP shape values.
Normal breathing during sleep is essential for people’s health and well-being. Therefore, it is crucial to diagnose apnoea events at an early stage and apply appropriate therapy. Detection of sleep apnoea is a central goal of the system design described in this article. To develop a correctly functioning system, it is first necessary to define the requirements outlined in this manuscript clearly. Furthermore, the selection of appropriate technology for the measurement of respiration is of great importance. Therefore, after performing initial literature research, we have analysed in detail three different methods and made a selection of a proper one according to determined requirements. After considering all the advantages and disadvantages of the three approaches, we decided to use the impedance measurement-based one. As a next step, an initial conceptual design of the algorithm for detecting apnoea events was created. As a result, we developed an activity diagram on which the main system components and data flows are visually represented.
A residual neural network was adapted and applied to the Physionet/Computing data in Cardiology Challenge 2020 to detect 24 different classes of cardiac abnormalities from 12-lead. Additive Gaussian noise, signal shifting, and the classification of signal sections of different lengths were applied to prevent the network from overfitting and facilitating generalization. Due to the use of a global pooling layer after the feature extractor, the network is independent of the signal’s length. On the hidden test set of the challenge, the model achieved a validation score of 0.656 and a full test score of 0.27, placing us 15th out of 41 officially ranked teams (Team name: UC_Lab_Kn). These results show the potential of deep neural networks for ap- plication to raw data and a complex multi-class multi-label classification problem, even if the training data is from di- verse datasets and of differing lengths.
Ballistocardiography (BCG) can be used to monitor heart rate activity. Besides, the accelerometer should have high sensitivity and minimal internal noise; a low-cost approach was taken into consideration. Several measurements have been executed to determine the optimal positioning of a sensor under the mattress to obtain a signal strong enough for further analysis. A prototype for an unobtrusive accelerometer-based measurement system has been developed and tested in a conventional bed without any specific extras. The influence of the human sleep position for the output accelerometer data was tested. The obtained results indicate the potential to capture BCG signals using accelerometers. The measurement system can detect heart rate in an unobtrusive form in the home environment.
The main aim of presented in this manuscript research is to compare the results of objective and subjective measurement of sleep quality for older adults (65+) in the home environment. A total amount of 73 nights was evaluated in this study. Placing under the mattress device was used to obtain objective measurement data, and a common question on perceived sleep quality was asked to collect the subjective sleep quality level. The achieved results confirm the correlation between objective and subjective measurement of sleep quality with the average standard deviation equal to 2 of 10 possible quality points.
Good sleep is crucial for a healthy life of every person. Unfortunately, its quality often decreases with aging. A common approach to measuring the sleep characteristics is based on interviews with the subjects or letting them fill in a daily questionnaire and afterward evaluating the obtained data. However, this method has time and personal costs for the interviewer and evaluator of responses. Therefore, it would be important to execute the collection and evaluation of sleep characteristics automatically. To do that, it is necessary to investigate the level of agreement between measurements performed in a traditional way using questionnaires and measurements obtained using electronic monitoring devices. The study presented in this manuscript performs this investigation, comparing such sleep characteristics as "time going to bed", "total time in bed", "total sleep time" and "sleep efficiency". A total number of 106 night records of elderly persons (aged 65+) were analyzed. The results achieved so far reveal the fact that the degree of agreement between the two measurement methods varies substantially for different characteristics, from 31 minutes of mean difference for "time going to bed" to 77 minutes for "total sleep time". For this reason, a direct exchange of objective and subjective measuring methods is currently not possible.
Polysomnography is a gold standard for a sleep study, and it provides very accurate results, but its cost (both personnel and material) are quite high. Therefore, the development of a low-cost system for overnight breathing and heartbeat monitoring, which provides more comfort while recording the data, is a well-motivated challenge. The system proposed in this manuscript is based on the usage of resistive pressure sensors installed under the mattress. These sensors can measure slight pressure changes provoked during breathing and heartbeat. The captured signal requires advanced processing, like applying filters and amplifiers before the analog signal is ready for the next step. Then, the output signal is digitalized and further processed by an algorithm that performs a custom filtering before it can recognize breathing and heart rate in real-time. The result can be directly visualized. Furthermore, a CSV file is created containing the raw data, timestamps, and unique IDs to facilitate further processing. The achieved results are promising, and the average deviation from a reference device is about 4bpm.
This work is a study about a comparison of survey tools and it should help developers in selecting a suited tool for application in an AAL environment. The first step was to identify the basic required functionality of the survey tools used for AAL technologies and to compare these tools by their functionality and assignments. The comparative study was derived from the data obtained, previous literature studies and further technical data. A list of requirements was stated and ordered in terms of relevance to the target application domain. With the help of an integrated assessment method, the calculation of a generalized estimate value was performed and the result is explained. Finally, the planned application of this tool in a running project is explained.
This paper presents the implementation of deep learning methods for sleep stage detection by using three signals that can be measured in a non-invasive way: heartbeat signal, respiratory signal, and movement signal. Since signals are measurements taken during the time, the problem is seen as time-series data classification. Deep learning methods are chosen to solve the problem are convolutional neural network and long-short term memory network. Input data is structured as a time-series sequence of mentioned signals that represent 30 seconds epoch, which is a standard interval for sleep analysis. The records used belong to the overall 23 subjects, which are divided into two subsets. Records from 18 subjects were used for training the data and from 5 subjects for testing the data. For detecting four sleep stages: REM (Rapid Eye Movement), Wake, Light sleep (Stage 1 and Stage 2), and Deep sleep (Stage 3 and Stage 4), the accuracy of the model is 55%, and F1 score is 44%. For five stages: REM, Stage 1, Stage 2, Deep sleep (Stage 3 and 4), and Wake, the model gives an accuracy of 40% and F1 score of 37%.
Für die Überwachung des Schlafs zu Hause sind nichtinvasive Methoden besonders gut anwendbar. Die Signale, die häufig überwacht werden, sind Herzfrequenz und Atemfrequenz. Die Ballistokardiographie (BCG)ist eine Technik, bei der die Herzfrequenz aus den mechanischen Schwingungen des Körpers bei jedem Herzzyklus gemessen wird. Kürzlich wurden Übersichtsarbeiten veröffentlicht. Die Untersuchung soll in einem ersten Ansatz bewerten, ob die Herzfrequenz anhand von BCG erkannt werden kann. Die wesentlichen Randbedingungen sind, ob dies gelingt, wenn der Sensor unter der Matratze positioniert wird und kostengünstige Sensoren zum Einsatz kommen.
Die Schlafapnoe ist eine häufig auftretende Schlafstörung,
die unterschiedliche Auswirkungen auf unseren Alltag hat; so wurde z. B.
über eine Tagesschläfrigkeit von etwa 25 % der Patienten mit obstruktiver
Schlafapnoe (OSA) berichtet. Ziel dieser Arbeit ist die Entwicklung eines
Systems, das eine nichtinvasive Erkennung der Schlafapnoe in häuslicher
Umgebung ermöglichen soll.
In diesem Beitrag wird eine Methode des maschinellen Lernens entwickelt, die die Schlafstadienerkennung untersucht. Übliche Methoden der Schlafanalyse basieren auf der Polysomnographie (PSG). Der präsentierte Ansatz basiert auf Signalen, die ausschließlich nicht-invasiv in einer häuslichen Umgebung gemessen werden können. Bewegungs-, Herzschlags- und Atmungssignale können vergleichsweise leicht erfasst werden aber die Erkennung der Schlafstadien ist dadurch erschwert. Die Signale werden als Zeitreihenfolge strukturiert und in Epochen überführt. Die Leistungsfähigkeit von maschinellem Lernen wird der Polysomnographie gegenübergestellt und bewertet.
This document presents a new complete standalone system for a recognition of sleep apnea using signals from the pressure sensors placed under the mattress. The developed hardware part of the system is tuned to filter and to amplify the signal. Its software part performs more accurate signal filtering and identification of apnea events. The overall achieved accuracy of the recognition of apnea occurrence is 91%, with the average measured recognition delay of about 15 seconds, which confirms the suitability of the proposed method for future employment. The main aim of the presented approach is the support of the healthcare system with the cost-efficient tool for recognition of sleep apnea in the home environment.
The ballistocardiography is a technique that measures the heart rate from the mechanical vibrations of the body due to the heart movement. In this work a novel noninvasive device placed under the mattress of a bed estimates the heart rate using the ballistocardiography. Different algorithms for heart rate estimation have been developed.
The recovery of our body and brain from fatigue directly depends on the quality of sleep, which can be determined from the results of a sleep study. The classification of sleep stages is the first step of this study and includes the measurement of vital data and their further processing. The non-invasive sleep analysis system is based on a hardware sensor network of 24 pressure sensors providing sleep phase detection. The pressure sensors are connected to an energy-efficient microcontroller via a system-wide bus. A significant difference between this system and other approaches is the innovative way in which the sensors are placed under the mattress. This feature facilitates the continuous use of the system without any noticeable influence on the sleeping person. The system was tested by conducting experiments that recorded the sleep of various healthy young people. Results indicate the potential to capture respiratory rate and body movement.
This document presents an algorithm for a non-obtrusive recognition of Sleep/Wake states using signals derived from ECG, respiration, and body movement captured while lying in a bed. As a core mathematical base of system data analytics, multinomial logistic regression techniques were chosen. Derived parameters of the three signals are used as the input for the proposed method. The overall achieved accuracy rate is 84% for Wake/Sleep stages, with Cohen’s kappa value 0.46. The presented algorithm should support experts in analyzing sleep quality in more detail. The results confirm the potential of this method and disclose several ways for its improvement.