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Know when you don't know
(2018)
Deep convolutional neural networks show outstanding performance in image-based phenotype classification given that all existing phenotypes are presented during the training of the network. However, in real-world high-content screening (HCS) experiments, it is often impossible to know all phenotypes in advance. Moreover, novel phenotype discovery itself can be an HCS outcome of interest. This aspect of HCS is not yet covered by classical deep learning approaches. When presenting an image with a novel phenotype to a trained network, it fails to indicate a novelty discovery but assigns the image to a wrong phenotype. To tackle this problem and address the need for novelty detection, we use a recently developed Bayesian approach for deep neural networks called Monte Carlo (MC) dropout to define different uncertainty measures for each phenotype prediction. With real HCS data, we show that these uncertainty measures allow us to identify novel or unclear phenotypes. In addition, we also found that the MC dropout method results in a significant improvement of classification accuracy. The proposed procedure used in our HCS case study can be easily transferred to any existing network architecture and will be beneficial in terms of accuracy and novelty detection.
Corporate Entrepreneurship (CE) has now evolved into an imperative innovation practice of established companies. Despite organizational design models for CE activities and companies' frequent initiation of new activities, effectively managing them remains a challenging endeavor which results in disappointment about the outcomes of CE and its early termination. We assume specific types of goals for CE as one element of this unresolved management issue. While both practice and literature address goals in different contexts, no uniform picture has emerged so far. Although goals are commonly used to categorize CE activities, they seldomly seem to be the core subject of investigation. Based on this preliminary analysis and consolidation, we put the goals of CE in focus. In a systematic literature review, we reveal aspects of goals to unmask the different types of goals and their underlying dimensions and characteristics. Our review contributes to a better understanding of goals by (1) organizing relevant literature on goals of CE in a specific classification process, (2) describing dimensions and attributes for a systematic classification of CE goals; and (3) providing a framework showing differences of goals for the CE context. We conclude with a discussion and hints for future research paths.