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A key objective of this research is to take a more detailed look at a central aspect of resilience in small and medium-sized enterprises (SMEs). A literature review and expert interviews were used to investigate which factors have an impact on the innovative capacity of start-ups and whether these can also be adapted by SMEs. First of all, it must be stated that there are considerable structural and process-related differences between start-ups and SMEs. These can considerably inhibit cooperation between the two forms of enterprise. However, in the same context, success factors and issues in the start-up sector could also be identified that can improve cooperation with SMEs. These and other findings are then discussed in both an economic and an academic context. This article was written as part of the research activities of the Smart Services Competence Centre (proper name: Kompetenzzentrum Smart Services), a central contact point for all questions in the area of smart service digitalization in Baden-Wuerttemberg. Here, companies can obtain information about various digital technologies and take advantage of various measures for the development of new ideas and innovative services (Kompetenzzentrum Smart Services BW: Über das Kompetenzzentrum, 2021).