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Interpretability and uncertainty modeling are important key factors for medical applications. Moreover, data in medicine are often available as a combination of unstructured data like images and structured predictors like patient’s metadata. While deep learning models are state-of-the-art for image classification, the models are often referred to as ’black-box’, caused by the lack of interpretability. Moreover, DL models are often yielding point predictions and are too confident about the parameter estimation and outcome predictions.
On the other side with statistical regression models, it is possible to obtain interpretable predictor effects and capture parameter and model uncertainty based on the Bayesian approach. In this thesis, a publicly available melanoma dataset, consisting of skin lesions and patient’s age, is used to predict the melanoma types by using a semi-structured model, while interpretable components and model uncertainty is quantified. For Bayesian models, transformation model-based variational inference (TM-VI) method is used to determine the posterior distribution of the parameter. Several model constellations consisting of patient’s age and/or skin lesion were implemented and evaluated. Predictive performance was shown to be best by using a combined model of image and patient’s age, while providing the interpretable posterior distribution of the regression coefficient is possible. In addition, integrating uncertainty in image and tabular parts results in larger variability of the outputs corresponding to high uncertainty of the single model components.
In Maun, Botswana, a self-sufficient, sustainable and future-oriented district will be created, the Maun Science Park. Within this project, several 5-8 storey smart homes shall be built in sustainable construction. The aim of this thesis is to develop a sustainable structural concept for those homes of the Maun Science Park. In a first step, the general basics for tall building structures and sustainable construction were established. Based on those fundamentals, criteria for the structural requirements, the ecological as well as the social sustainability of a structural design could be defined. Subsequently, four structural systems were drafted: a concrete core structure, a steel shear frame structure, a rammed earth shear wall structure and a wooden diagrid structure. In addition to the pre-dimensioning of the systems, a life cycle assessment was set up to evaluate the ecological sustainability of the designs. With the help of a utility value analysis, the wooden diagrid structure was determined as the preferred variant. The comparison of the designs also allows to draw general conclusions for the development of sustainable tall building structures. The results of the life cycle assessment show the advantage of wood as an ecological building material over industrially manufactured building materials, such as steel and concrete. Whereas rammed earth, a likewise ecological building material, is not convincing due to its low strength. In general, a balance is created in the life cycle assessment between ecological and industrially manufactured products in regard of strength and environmental impact. In terms of social sustainability, the design of the structure system can significantly influence the flexibility and use of local resources. However, due to the diversity of sustainable construction, the development of a structural system should be linked to an overarching sustainability concept that takes architecture and stakeholders into account.