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The transformation to an Industry 4.0, which is in general seen as a solution to increasing market challenges, is forcing companies to radically change their way of thinking and to be open to new forms of cooperation. In this context, the opening-up of the innovation process is widely seen as a necessity to meet these challenges, especially for small and medium enterprises (SMEs). The aim of the study therefore is to analyze how cooperation today can be characterized, how this character has changed since the establishment of the term Industry 4.0 at Hanover Fair in 2011 and which cooperation strategies have proven successful. The analysis consists of a quantitative, secondary data analysis that includes country-specific data from 35 European countries of 2010 and 2016 collected by the European Commission and the OECD. The research, focusing on the secondary sector, shows that multinational enterprises MNEs still tend to cooperate more than SMEs, with a slight overall trend towards protectionism. Nevertheless, there is a clear tendency towards the opening-up of SMEs. In this regard, especially universities, competitors and suppliers have become increasingly attractive as cooperation partners for SMEs.