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Know when you don't know
(2018)
Deep convolutional neural networks show outstanding performance in image-based phenotype classification given that all existing phenotypes are presented during the training of the network. However, in real-world high-content screening (HCS) experiments, it is often impossible to know all phenotypes in advance. Moreover, novel phenotype discovery itself can be an HCS outcome of interest. This aspect of HCS is not yet covered by classical deep learning approaches. When presenting an image with a novel phenotype to a trained network, it fails to indicate a novelty discovery but assigns the image to a wrong phenotype. To tackle this problem and address the need for novelty detection, we use a recently developed Bayesian approach for deep neural networks called Monte Carlo (MC) dropout to define different uncertainty measures for each phenotype prediction. With real HCS data, we show that these uncertainty measures allow us to identify novel or unclear phenotypes. In addition, we also found that the MC dropout method results in a significant improvement of classification accuracy. The proposed procedure used in our HCS case study can be easily transferred to any existing network architecture and will be beneficial in terms of accuracy and novelty detection.
Knot placement for curve approximation is a well known and yet open problem in geometric modeling. Selecting knot values that yield good approximations is a challenging task, based largely on heuristics and user experience. More advanced approaches range from parametric averaging to genetic algorithms.
In this paper, we propose to use Support Vector Machines (SVMs) to determine suitable knot vectors for B-spline curve approximation. The SVMs are trained to identify locations in a sequential point cloud where knot placement will improve the approximation error. After the training phase, the SVM can assign, to each point set location, a so-called score. This score is based on geometric and differential geometric features of points. It measures the quality of each location to be used as knots in the subsequent approximation. From these scores, the final knot vector can be constructed exploring the topography of the score-vector without the need for iteration or optimization in the approximation process. Knot vectors computed with our approach outperform state of the art methods and yield tighter approximations.