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Healthy and good sleep is a prerequisite for a rested mind and body. Both form the basis for physical and mental health. Healthy sleep is hindered by sleep disorders, the medically diagnosed frequency of which increases sharply from the age of 40. This chapter describes the formal specification of an on-course practical implementation for a non-invasive system based on biomedical signal processing to support the diagnosis and treatment of sleep-related diseases. The system aims to continuously monitor vital data during sleep in a patient’s home environment over long periods by using non-invasive technologies. At the center of the development is the MORPHEUS Box (MoBo), which consists of five main conceptualizations: the MoBo core, the MoBo-HW, the MoBo algorithm, the MoBo API, and the MoBo app. These synergistic elements aim to support the diagnosis and treatment of sleep-related diseases. Although there are related developments in individual aspects concerning the system, no comparative approach is known that gives a similar scope of functionality, deployment flexibility, extensibility, or the possibility to use multiple user groups. With the specification provided in this chapter, the MORPHEUS project sets a good platform, data model, and transmission strategies to bring an innovative proposal to measure sleep quality and detect sleep diseases from non-invasive sensors.
Die Erholung unseres Körpers und Gehirns von Müdigkeit ist direkt abhängig von der Qualität des Schlafes, die aus den Ergebnissen einer Schlafstudie ermittelt werden kann. Die Klassifizierung der Schlafstadien ist der erste Schritt dieser Studie und beinhaltet die Messung von Biovitaldaten und deren weitere Verarbeitung. Das non-invasive Schlafanalyse-System basiert auf einem Hardware-Sensornetz aus 24 Drucksensoren, das die Schlafphasenerkennung ermöglicht. Die Drucksensoren sind mit einem energieeffizienten Mikrocontroller über einen systemweiten Bus mit Adressarbitrierung verbunden. Ein wesentlicher Unterschied dieses Systems im Vergleich zu anderen Ansätzen ist die innovative Art, die Sensoren unter der Matratze zu platzieren. Diese Eigenschaft erleichtert die kontinuierliche Nutzung des Systems ohne fühlbaren Einfluss auf das gewohnte Bett. Das System wurde getestet, indem Experimente durchgeführt wurden, die den Schlaf verschiedener gesunder junger Personen aufzeichneten. Die ersten Ergebnisse weisen auf das Potenzial hin, nicht nur Atemfrequenz und Körperbewegung, sondern auch Herzfrequenz zu erfassen.
Polysomnography is a gold standard for a sleep study, and it provides very accurate results, but its cost (both personnel and material) are quite high. Therefore, the development of a low-cost system for overnight breathing and heartbeat monitoring, which provides more comfort while recording the data, is a well-motivated challenge. The system proposed in this manuscript is based on the usage of resistive pressure sensors installed under the mattress. These sensors can measure slight pressure changes provoked during breathing and heartbeat. The captured signal requires advanced processing, like applying filters and amplifiers before the analog signal is ready for the next step. Then, the output signal is digitalized and further processed by an algorithm that performs a custom filtering before it can recognize breathing and heart rate in real-time. The result can be directly visualized. Furthermore, a CSV file is created containing the raw data, timestamps, and unique IDs to facilitate further processing. The achieved results are promising, and the average deviation from a reference device is about 4bpm.
This thesis presents the development of two different state-feedback controllers to solve the trajectory tracking problem, where the vessel needs to reach and follow a time-varying reference trajectory. This motion problem was addressed to a real-scaled fully actuated surface vessel, whose dynamic model had unknown hydrodynamic and propulsion parameters that were identified by applying an experimental maneuver-based identification process. This dynamic model was then used to develop the controllers. The first one was the backstepping controller, which was designed with a local exponential stability proof. For the NMPC, the controller was developed to minimize the tracking error, considering the thrusters’ constraints. Moreover, both controllers considered the thruster allocation problem and counteracted environmental disturbance forces such as current, waves and wind.The effectiveness of these approaches was verified in simulation using Matlab/Simulink and GRAMPC (in the case of the NMPC), and in experimental scenarios, where they were applied to the vessel, performing docking maneuvers at the Rhine River in Constance (Germany).
A nonlinear mathematical model for the dynamics of permanent magnet synchronous machines with interior magnets is discussed. The model of the current dynamics captures saturation and dependency on the rotor angle. Based on the model, a flatness-based field-oriented closed-loop controller and a feed-forward compensation of torque ripples are derived. Effectiveness and robustness of the proposed algorithms are demonstrated by simulation results.
In this paper, a gain-scheduled nonlinear control structure is proposed for a surface vessel, which takes advantage of extended linearisation techniques. Thereby, an accurate tracking of desired trajectories can be guaranteed that contributes to a safe and reliable water transport. The PI state feedback control is extended by a feedforward control based on an inverse system model. To achieve an accurate trajectory tracking, however, an observer-based disturbance compensation is necessary: external disturbances by cross currents or wind forces in lateral direction and wave-induced measurement disturbances are estimated by a nonlinear observer and used for a compensation. The efficiency and the achieved tracking performance are shown by simulation results using a validated model of the ship Korona at the HTWG Konstanz, Germany. Here, both tracking behaviour and rejection of disturbance forces in lateral direction are considered.
Notizen zur Stadtbaukunst
(2021)
Bedarf es heute einer institutionalisierten Stadtbaukunst? Als Gegenbewegung zur schematischen, mechanischen Stadterweiterungspraxis entwickelte sich Stadtbaukunst gegen Ende des 19. Jahrhunderts und fand in Praxis und Diskurs ihren Höhepunkt vor dem Ersten Weltkrieg. Seit einigen Jahren wird nun von verschiedenen Seiten deren Neuentdeckung und Neubewertung eingefordert. Doch die Lage heute ist eine andere als die vor über hundert Jahren. Was bedeutet das für die Idee einer Stadtbaukunst im Zusammenspiel mit Städtebau, Architektur und Stadtplanung?
Study design:
Retrospective, mono-centric cohort research study.
Objectives:
The purpose of this study is to validate a novel artificial intelligence (AI)-based algorithm against human-generated ground truth for radiographic parameters of adolescent idiopathic scoliosis (AIS).
Methods:
An AI-algorithm was developed that is capable of detecting anatomical structures of interest (clavicles, cervical, thoracic, lumbar spine and sacrum) and calculate essential radiographic parameters in AP spine X-rays fully automatically. The evaluated parameters included T1-tilt, clavicle angle (CA), coronal balance (CB), lumbar modifier, and Cobb angles in the proximal thoracic (C-PT), thoracic, and thoracolumbar regions. Measurements from 2 experienced physicians on 100 preoperative AP full spine X-rays of AIS patients were used as ground truth and to evaluate inter-rater and intra-rater reliability. The agreement between human raters and AI was compared by means of single measure Intra-class Correlation Coefficients (ICC; absolute agreement; .75 rated as excellent), mean error and additional statistical metrics.
Results:
The comparison between human raters resulted in excellent ICC values for intra- (range: .97-1) and inter-rater (.85-.99) reliability. The algorithm was able to determine all parameters in 100% of images with excellent ICC values (.78-.98). Consistently with the human raters, ICC values were typically smallest for C-PT (eg, rater 1A vs AI: .78, mean error: 4.7°) and largest for CB (.96, -.5 mm) as well as CA (.98, .2°).
Conclusions:
The AI-algorithm shows excellent reliability and agreement with human raters for coronal parameters in preoperative full spine images. The reliability and speed offered by the AI-algorithm could contribute to the efficient analysis of large datasets (eg, registry studies) and measurements in clinical practice.
The main goal of this work was to experimentally characterize the hot air-drying process of agricultural products (Potato, Carrot, Tomato) and verify it with numerical solutions at single layer and industrial scale dryer using Comsol Multiphysics® 5.3.
Input parameters at single layer dryer effects on quality attributes were examined. Two strategies of drying were applied on batch dryer to examine the input effects on quality attributes. Constant input parameters strategy was designed by using central composite design formulation and optimized by Response Surface Methodology (RSM). The second strategy was applied for further optimization of the selected region by using square wave profile of the air temperature and relative humidity. Similarly, numerical method for single layer dryer, unsteady-state partial differential equations have been solved by means of the Finite Elements Method coupled to the Arbitrary Lagrangian-Eulerian (ALE). Also, for batch dryer, the mechanistic mathematical models of coupled heat and mass transfer were developed and solved as solid porous moist material.
With this work, the process of convective drying of agricultural products could be optimized. Furthermore, important knowledge about the basic mechanisms of the drying process was found and implemented in the numerical models.